| Class/Drug | Usual Adult Daily Dosing** | Special Considerations |
|---|---|---|
| Nucleotide Reverse Transcriptase Inhibitors | ||
| VireadTM (tenofovir disoproxil fumarate) |
1 x 300mg tablet 1 time a day | Take after a meal |
| Nucleoside Reverse Transcriptase Inhibitors | ||
| Emtriva® (emtricitabine) |
1 x 200mg capsule 1 time a day | |
| Trizivir® (abacavir sulfate, lamivudine, and zidovudine) |
1 tablet 2 times a day | |
| Combivir ® (lamivudine/zidovudine) |
1 x 150mg/300mg tablet 2 times a day | Should not be prescribed for patients requiring dosage adjustments. |
| Epivir ® (lamivudine - also known as 3TC) |
1 x 150mg tablet 2 times a day | |
| Zerit ® (stavudine - also known as d4T) |
1 x 40mg capsule 2 times a day | |
| Ziagen ® (abacavir sulfate) |
1 x 300mg tablet 2 times a day | |
| Hivid ® (zalcitabine - also known as ddC) |
1 x 0.75mg tablet 3 times a day | Should not be used concomitantly with didanosine. Do not take simultaneously with magnesium/aluminum containing antacids. |
| Videx® EC (didanosine - also known as ddl) |
1 x 400mg tablet 1 time a day | Take on empty stomach, at least 30 minutes before or 2 hours after eating. Alcohol may exacerbate toxicity. |
| Retrovir® (zidovudine - also known as ZDV or AZT) |
2 x 100mg capsules 3 times a day or 1 x 300mg tablet 2 times a day. | Take with food to lessen gastrointestinal side effects |
| Non-Nucleoside Reverse Transcriptase Inhibitors | ||
| Viramune® (nevirapine) |
1 x 200mg tablet 2 times a day | Lead in dosing for the first 14 days of therapy |
| Sustiva ® (efavirenz) |
3 x 200mg capsules or 1 x 600mg tablet 1 time a day |
To improve tolerability of nervous system side effects, bedtime dosing is recommended during the first 2-4 weeks of therapy and in patients who continue to experience these symptoms. High fat meals should be avoided. |
| Rescriptor ® (delavirdine mesylate) |
4 x 100mg tablets or 2 x 200 mg tablets 3 times a day | Should be taken at least 1 hour apart from didanosine and from antacids. |
| Protease Inhibitors | ||
| ReyatazTM (atazanavir sulfate) |
2 x 200mg capsules 1 time a day or 2 x 150mg capsules 1 time a day when boosted with 100mg of Norvir® | Take with food. Talk to your doctor about medications that should NOT be taken with ReyatazTM |
| KaletraTM (lopinavir/ritonavir) |
3 capsules every 12 hours | Take with food. Should be refrigerated, but may be stored at controlled room temperature for 60 days. |
| Crixivan® (indinavir) |
2 x 400mg capsules every 8 hours (200mg capsules available as a supplemental dose) | Take on empty stomach 1 hour before or 2 hours after a meal. Drink at least 1.5 liters of liquid daily. |
| Invirase® (saquinavir mesylate) |
3 x 200mg hard gelatin capsules 3 times a day | Take within 2 hours after a full meal. Saquinavir taken without food may have less bioavailability. |
| Fortovase® (saquinavir) |
6 x 200mg soft gelatin capsules 3 times a day | Take within 2 hours after a full meal. Saquinavir taken without food may have less bioavailability. |
| Viracept® (nelfinavir mesylate) |
5 x 250mg tablets 2 times a day | Take with a meal or a light snack |
| Norvir® (ritonavir) |
6 x 100mg capsules 2 times a day | Should be refrigerated, but may be stored at controlled room temperature for 30 days. Take with meals. Titrated lead-in dosing: start at no less than 300mg bid; increase by 100mg increments bid up to 600mg bid. |
| Agenerase® (amprenavir) |
8 x 150mg capsules 2 times a day | Take on empty stomach or with light snack. Avoid taking with high fat foods. Patients should not take supplemental Vitamin E with Agenerase. |
* Based on manufacturer's prescribing information
** Based on adults weighing > 60kg
Viread and Emtriva are trademarks of Gilead Sciences, Inc. Rescriptor is a registered trademark of Pharmacia & Upjohn Company. trizivir, Combivir, Epivir, Ziagen, Agenerase and Retrovir are registered trademarks of GlaxoSmithKline, Inc. Zerit, Videx, and Reyataz are registered trademarks of Bristol-Myers Squibb Company. Hivid and Invirase are registered trademarks and Fortovase is a trademark of Roche Laboratories. Crixivan is a registered trademark of Merck & Co., Inc. Viracept is a registered trademark of Agouron Pharmaceuticals, Inc. Viramune is a registered trademark of Boehringer Ingelheim Pharmaceuticals, Inc. Norvir and Kaletra are trademarks of Abbott Laboratories. Sustiva is a trademark of DuPont Pharmaceuticals Company.